Landslides are the most frequent natural disaster in Nepal. As such, the scientific study of the Nepal landslides has been in progress for several years, but no significant achievement has been made in preventing landslides and mitigating disaster damage yet. As one important aspect of dealing with landslides is understanding their distribution pattern based on geological and geomorphological formations, this paper addresses these issues, and attempts to present a scenario of large-scale landslide distribution along the road corridors of major highways in central Nepal. As a result of landslide mapping using aerial photographs, topographical maps, and field verification, the following points were understood: 1) the distribution of large-scale landslides is relatively dense over the area close to tectonic thrusts, 2) slate and phyllite zones have a greater ratio of landslide distribution, and 3) topographies with a mean slope angle of about 27 to 36 degrees have denser distribution of large-scale landslides.