At present, slope is one of the three major sources of geological disasters, and disasters caused by slope happened frequently. The index system of rock slope safety for open pit mine was comprehensively researched by the model of fuzzy  evaluation  and  the  analytic  hierarchy  process.  The  technical methods  on  the  selection and resolution  of  the  index system of rock slope safety evaluation for open pit mine, and the confirmation of weight of safety evaluation index system had been obtained. The comprehensive index system of rock slope safety evaluation for open pit mine can consist of 28 safety indexes which include 5 aspects (rock slope quality, slope morphology, human factors, slope safety management and other factors).