Lakes can be used as model basins to investigate subaqueous slope stability under static and dynamic loading conditions. This study combines geophysical, sedimentological and in situ geotechnical methods with limit equilibrium calculations in order to discuss (i) the geological and sedimentological processes acting on submerged non-deltaic lateral slopes in perialpine, fjord-type Lake Lucerne (Central Switzerland); (ii) their control on physical and geotechnical properties that eventually affect the subaqueous stability conditions and slope failure initiation, and (iii) the quantitative assessment of subaqueous slope stability. Three detailed case studies are presented to describe and quantitatively reconstruct stability conditions of slopes that failed during a well-documented historic earthquake in 1601 A.D. and during a prehistoric Late Holocene earthquake around 2220 cal yr BP (both MwN6).