Coloumbo submarine volcano lies 6.5 km offshore the NE part ofthe Santorini island complex and exhibits high seismicity along with vigorous hydrothermal activity. This study models the local stress field around Coloumbo’s magma chamber and investigates its influence on intrusion emplacement and geometry. The two components of the stress field, hoop and radial stress, are calculated using analytical formulas that take into accountthe depth and radius of the magma chamber as these are determined from seismological and other observations. These calculations indicate that hoop stress at the chamber walls is maximum at anangle of 74◦ thus favouringflank intrusions, while the radial stress switches fromtensile to compressive at a critical distance of 5.7 km from the center of the magma chamber. Such estimates agree well with neotectonic and seismological observations that describe the local/regional stress field in the area. We analyse in detail the case where a flank intrusion reaches the surface very near the NE coast of Thera as this is the worst-case eruption scenario. The geometrical features of such a feeder dyke point to an average volumetric flow rate of 9.93 m3 s−1 which corresponds to a Volcanic Explosivity Index of 3 if a future eruption lasts about 70 days. Hazards associated with such an eruption include ashfall, ballistic ejecta and base surges due to explosive mixing of magma with seawater. Previous studies have shown that areas near erupting vents are also foci of moderate to large earthquakes that precede or accompany an eruption. Our calculations show that a shallow event (3–5 km) of moment magnitude 5.9 near the eruptive vent may cause Peak Ground Acceleration in the range 122–177 cm s−2 at different locations around Santorini. These values indicate that seismic hazard even due to a moderate earthquake near Coloumbo, is not trivial and may have a significant impact especially on older buildings at Thera island.