Holocene and Pleistocene tectonic deformation of the coast in the Mexico subudction margin is recorded by geomorphic and stratigraphic markers. We document the spatial and temporal variability of active deformation on the coastal Mexican subduction margin. Pleistocene uplift rates are estimated using wave-cut platforms at ca. 0.7–0.9 m/ka on the Jalisco block coast, Rivera-North America tectonic plate boundary. We examine reported measurements from marine notches and shoreline angle elevations in conjunction with their radiocarbon ages that indicate surface uplift rates increasing during the Holocene up to ca. 3 ± 0.5 m/ka. In contrast, steady rates of uplift (ca. 0.5–1.0 m/ka) in the Pleistocene and Holocene characterize the Michoacan coastal sector, south of El Gordo graben and north of the Orozco Fracture Zone (OFZ), incorporated within the Cocos-North America plate boundary. Significantly higher rates of surface uplift (ca. 7 m/ka) across the OFZ subduction may reflect the roughness of subducting plate. Absence of preserved marine terraces on the coastal sector across El Gordo graben likely reflects slow uplift or coastal subsidence. Stratigraphic markers and their radiocarbon ages show late Holocene (ca. last 6 ka BP) coastal subsidence on the Guerrero gap sector in agreement with a landscape barren of marine terraces and with archeological evidence of coastal subsidence. Temporal and spatial variability in recent deformation rates on the Mexican Pacific coast may be due to differences in tectonic regimes and to localized processes related to subduction, such as crustal faults, subduction erosion and underplating of subducted materials under the southern Mexico continental margin.